Clozapine

Information about Clozapine

Clozapine Uses

Clozapine is used in the treatment of schizophrenia.

How Clozapine works

Clozapine is an atypical antipsychotics. It works by modulating the action of certain chemical messengers in the brain that affects thoughts.

Common side effects of Clozapine

Dizziness, Fainting, Constipation, Fever, Weight gain, Decreased white blood cell count, Extrapyramidal symptoms, Increased liver enzymes, Drowsiness, Seizure, Increased white blood cell count (eosinophils), Anticholinergic effects, Tachycardia, Excessive salivation
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Varun Gupta
MD Pharmacology, MBBS
Last updated
13 Jun 2023 | 11:26 AM (UTC)

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Available Medicine for Clozapine

Expert advice for Clozapine

  • Clozapine helps treat schizophrenia in people for whom other medicines are ineffective or not tolerated.
  • Take it with or without food, preferably at the same time everyday.
  • It can cause dizziness and sleepiness. Be cautious while driving or doing anything that requires concentration.
  • It may cause low blood pressure and dehydration. Drink plenty of fluids and rise slowly from a sitting or lying position.
  • It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
  • Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Do not stop taking Clozapine without talking  to your doctor first as it may cause worsening of symptoms.

Frequently asked questions for Clozapine

Clozapine

Q. How long does it take for Clozapine to work?

Like many medicines, Clozapine does not work straight away. You might start feeling more calm and relaxed after a few weeks of taking this medicine.

Q. Why has Clozapine been prescribed?

Clozapine is an antipsychotic drug used to treat manic episodes and Schizophrenia, a mood disorder. It shortens the time to recovery and prevents mania from returning. It is also used to reduce the risk of suicidal behavior in people with Schizophrenia.

Q. Does Clozapine help with anxiety?

Yes, Clozapine helps calm the mind and decreases the level of anxiety and aggressive behavior in patients with Schizophrenia.

Q. Is Clozapine addictive?

No, Clozapine is not addictive in nature. No habit-forming potential has been seen with its use. However, always follow your doctor's advice regarding the duration of its use.

Q. When should I see my doctor?

Seek immediate medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction, pain or burning when you urinate, or vaginal itching or discharge.

Q. Can Clozapine cause dizziness?

Yes. Clozapine can cause dizziness by reducing blood pressure. If this happens to you, you should sit or lie down until the symptoms pass. Always carry some sugary food or fruit juice with you in case you experience dizziness while traveling.

Q. Why do I have to have regular blood tests while I am taking Clozapine?

Clozapine is known to cause a rare but serious side effect called “agranulocytosis”. This side effect occurs in less than 1 out of every 100 people who take this medicine. This side effect can result in a decrease in the number of white blood cells (infection-fighting cells) in your body. Without enough white blood cells, your body may not be able to. In order to prevent this, your doctor may prescribe you a blood test to check your white blood cell count.

Q. Can I drink alcohol while taking Clozapine?

It is recommended that people taking this medicine should not drink alcohol. This is because Clozapine is an antipsychotic and taking it with alcohol can cause severe drowsiness. This can lead to falls and accidents. Also, drinking alcohol may make mania, depression, and anxiety worse. Discuss any concerns you have with your doctor, pharmacist, or nurse.

Q. I am experiencing a change in my taste after the start of the treatment with Clozapine. Any tips to reduce it?

A change in taste is a common side-effect of this medicine. Rinse your mouth with a solution of salt and bicarbonate of soda before mealtimes to neutralize the bad taste in your mouth. You may also add some extra flavor or seasonings to your food.

Q. I am having trouble remembering to take my medications. Is there anything I can do to help me remember?

In order to avoid missing a dose, use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member a friend to remind you or check in with you to be sure you are taking your medication.

Q. What happens if I stop taking Clozapine?

It is advisable not to stop taking this medicine without talking to your doctor, since it may worsen your symptoms. Your doctor will probably want to decrease your dose gradually.

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