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MD (Pharmacology), MBBS
Last updated
26 Dec 2023 | 11:24 AM (IST)

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Calmac 50 Tablet

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Product introduction

Calmac 50 Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Calmac 50 Tablet is used in treating prostate cancer that require certain male body chemicals to grow

Uses of Calmac Tablet


Side effects of Calmac Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Calmac

  • Anemia (low number of red blood cells)
  • Rash
  • Abdominal pain
  • Breast enlargement in male
  • Breast tenderness
  • Constipation
  • Decreased appetite
  • Decreased libido
  • Depression
  • Dizziness
  • Indigestion
  • Flatulence
  • Hot flashes
  • Increased liver enzymes
  • Nausea
  • Sleepiness
  • Weakness
  • Weight gain

How to use Calmac Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Calmac 50 Tablet may be taken with or without food, but it is better to take it at a fixed time.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Calmac 50 Tablet. Please consult your doctor.
Pregnancy
UNSAFE
Calmac 50 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Calmac 50 Tablet during breastfeeding is not available. Please consult your doctor.
Driving
SAFE
Calmac 50 Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Calmac 50 Tablet is safe to use in patients with kidney disease. No dose adjustment of Calmac 50 Tablet is recommended.
Liver
CAUTION
Calmac 50 Tablet should be used with caution in patients with liver disease. Dose adjustment of Calmac 50 Tablet may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advisable while you are taking this medicine.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Calmac 50 Tablet
₹48.4/Tablet
₹43.25/tablet
11% cheaper
Caluran 50 CP Tablet
Sun Pharmaceutical Industries Ltd
₹18.5/tablet
62% cheaper
Tabi Tablet
Dr Reddy's Laboratories Ltd
₹48.49/tablet
same price
Caluran 50 Tablet
Sun Pharmaceutical Industries Ltd
₹23.6/tablet
51% cheaper
Utamide Tablet
Intas Pharmaceuticals Ltd
₹43.25/tablet
11% cheaper

Quick tips

  • You have been prescribed Calmac 50 Tablet for the treatment of prostate cancer.
  • Take it with or without food, preferably at the same time every day.
  • It may cause your skin to become light sensitive. Avoid direct exposure to excessive sunlight and use sunscreen when outdoors.
  • If you are diabetic, monitor your blood glucose regularly while taking Calmac 50 Tablet.
  • Your doctor may want you to have regular blood tests to monitor your liver function while you are taking this medicine. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Do not stop taking the medication without talking to your doctor first.

Fact Box

Chemical Class
Trifluoromethylbenzenes Derivative
Habit Forming
No
Therapeutic Class
abcde
Action Class
Androgen receptor antagonist

Patient concerns

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Dr. Sir, I have facing depression again after 2 year , and I don't know what was it's triggered point. Kindly tell me what should i do in this situation, I am bachelor. Is Zyven is good for this situation as it was earlier suggest by psychiatrist.
Dr. Jyoti Kapoor Madan
Psychiatry
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
Hysterectomy ovaries removed body ache night sweats
Dr. Megha Gupta
Obstetrics and Gynaecology
Such problems are common after getting ovaries removed. Do not worry, these problems will eventually fade with time. However if it causes discomfort and restlessness, you should see your gynaecologist for hormonal replacement therapy
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FAQs

Can Calmac 50 Tablet cause infertility?

There is limited data to support that Calmac 50 Tablet causes infertility. Calmac 50 Tablet has been shown to affect fertility in animals and therefore it is assumed that it may cause fertility on humans. Some studies have shown that it affects spermatogenesis (origin and development of the sperm cells).

What should I avoid while taking Calmac 50 Tablet?

Skin sensitivity has been observed in some patients while taking Calmac 50 Tablet. Therefore, you should avoid direct sun exposure, sunlamps, and tanning beds. It is advised to use a sunscreen during treatment with Calmac 50 Tablet.

Is Calmac 50 Tablet a form of chemotherapy?

No, Calmac 50 Tablet is not a form of chemotherapy medicine, it is anti-androgen medicine. Androgens such as testosterone are natural male sex hormones. Calmac 50 Tablet works by blocking the effect of androgens (testosterone) in order to stop the growth and spread of cancer cells.

Does Calmac 50 Tablet cause hair loss?

Yes, Calmac 50 Tablet may cause hair loss as it is a common side effect. However, this does not affect everyone. Consult your doctor, if hair loss is worrying you.

What is Calmac 50 Tablet prescribed for?

Calmac 50 Tablet is used with another medication (gonadotropin-releasing hormone (GnRH) agonists; such as leuprolide or goserelin) to treat metastatic prostate cancer (prostate cancer that has spread to other parts of the body). Other than that, Calmac 50 Tablet has been effective in treating hirsutism in patients with polycystic ovarian disease, though this is not an approved use.

When should I take Calmac 50 Tablet?

Calmac 50 Tablet should be taken at the same time every day either in the morning or in the evening. Take it exactly as directed by your doctor.

Can Calmac 50 Tablet cause diarrhea?

Yes, Calmac 50 Tablet can cause diarrhea though it is rare. Generally, constipation is more common with this medicine. Consult your doctor if it worries you.

How long do I need to take Calmac 50 Tablet?

Calmac 50 Tablet tablets should be taken continuously for a minimum of 2 years or until the disease persists. Do not stop taking it without consulting your doctor.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1766.
  2. Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 724.
  3. Bicalutamide. Sellersville, PA: TEVA Pharmaceutical; 1995 [revised Jun. 2009]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  4. Bicalutamide. Capability Green: AstraZeneca UK; 2000 [revised 08 Feb. 2018]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

Marketer details

Name: Admac Pharma Ltd
Address: SCO 84, Sector 5, Panchkula (Haryana), 134112 INDIA.
Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.

MRP
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10.0 tablets in 1 strip
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