Knogle 200IU Nasal Spray is a medicine used for the treatment of osteoporosis in postmenopausal women. It makes the bones stronger and lowers the risk of fractures. It may also be used for bone pain associated with Paget's disease.

Knogle 200IU Nasal Spray should be used as you have been advised by your doctor. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other, and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril. You should take adequate supplements of calcium and vitamin D while on the treatment of this medicine to make it more effective.

The most common side effects of this medicine include runny nose, nose bleed, back pain, joint pain, headache, and other nose symptoms such as itching, irritation, and discomfort. These are usually mild but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problems with your heart, kidneys, or liver. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of Knogle Nasal Spray

Post menopausal osteoporosis
Paget's disease

Benefits of Knogle Nasal Spray

In Post menopausal osteoporosis

Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Knogle 200IU Nasal Spray slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. Use it as advised by the doctor and follow your doctor’s instructions carefully.

In Paget's disease

Paget’s disease is a condition that disrupts the replacement of old bone tissue with new bone tissue. Knogle 200IU Nasal Spray decreases the bone degeneration and helps in regeneration of healthy bone tissue. You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

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Side effects of Knogle Nasal Spray

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Knogle

Runny nose
Nosebleeds
Nasal irritation
Back pain
Joint pain
Headache

How to use Knogle Nasal Spray

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.

How Knogle Nasal Spray works

Knogle 200IU Nasal Spray is a calcitonin receptor agonist. It acts by suppressing the activity of osteoclasts, cells that cause destruction of bone, thereby strengthening the bones and minimizing the risk of fractures.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

Knogle 200IU Nasal Spray may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Knogle 200IU Nasal Spray is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

What if you forget to take Knogle Nasal Spray?

If you miss a dose of Knogle 200IU Nasal Spray, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Knogle 200IU Nasal Spray

₹1650.0/Nasal Spray

Calcinase Nasal Spray

Cipla Ltd

₹1860.06/nasal spray

13% costlier

Gemcal Nasal Spray

Alkem Laboratories Ltd

₹2180/nasal spray

32% costlier

Calcispray Nasal Spray

Zydus Cadila

₹2107.9/nasal spray

28% costlier

Uptonin Nasal Spray

Viilbery Healthcare Pvt Ltd

₹1650/nasal spray

same price

Miacalcic Nasal 200

Novartis India Ltd

₹1596/nasal spray

3% cheaper

View all substitutes

Quick tips

You have been prescribed Knogle 200IU Nasal Spray to make your bones stronger, and lower the risk of fractures.
It is used in women with osteoporosis who have undergone menopause.
It may cause temporary dizziness. Don't drive or do anything requiring concentration until you know how it affects you.
Unopened bottles should be stored in the refrigerator. Once opened, they should be stored at room temperature for up to 35 days.
Stop using it and inform your doctor if you get any nosebleeds or notice any ulceration inside your nose.
Discontinue Knogle 200IU Nasal Spray and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.

Fact Box

Chemical Class

Hormones

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone resorption inhibitors- Calcitonin

Patient concerns

I had hot flash, sweating and ganrahat

Dr. Pushkar Mani

Physician

Seems like post menopausal syndrome. Visit a gynaecologist.

Ovaries taken out chest pain and intense sweat high heart beats

Dr. Suman Rao

Obstetrics and Gynaecology

These are the symptoms of menopause. Consult a gynaec nearby and discuss about post menopausal therapy

Having urine burning problem past month. with the homeop medicine 70% relief i got. now i stopped medicine to have. five year back hystectomy done overies still remain. due to computer work eyes get dried and tired. shoulders also pain. past 1.7 year back pain started. some time hot flashes also come suddenly. all blood investigation and u/s are normal. as per dr. advise take sweet less. hair fall are more. no dandruff.

Dr. Megha Gupta

Obstetrics and Gynaecology

It is normal to have hot flashes and these post menopausal symptoms after hysterectomyYou can take hormone therapy if you want however symptoms will recurrent when you stop treatment

FAQs

Does Knogle 200IU Nasal Spray need to be refrigerated?

Yes, an unopened bottle of Knogle 200IU Nasal Spray need to be refrigerated. It should be kept at a temperature between 2°C and 8°C. Do not freeze. After opening the bottle of Knogle 200IU Nasal Spray, store it at room temperature between 15°C and 30°C.

Does Knogle 200IU Nasal Spray increase bone density?

Knogle 200IU Nasal Spray contains calcitonin which is a hormone that is naturally produced by the thyroid gland and is responsible for maintaining calcium balance in the body. Knogle 200IU Nasal Spray decreases the bone loss and damage in patients with osteoporosis. In some cases, it also helps in bone formation by activating the bone forming cells, thereby increasing the bone density.

Can Knogle 200IU Nasal Spray reduce the calcium levels in blood?

Yes, Knogle 200IU Nasal Spray can reduce the levels of calcium in the blood. If the calcium levels in your blood drop down severely then it can present with numbness or tingling in your fingers, toes, or around your mouth. The blood calcium levels need to be monitored in such cases. Immediately contact your doctor if you experience any such symptoms.

How should I use Knogle 200IU Nasal Spray?

Follow the directions given by your prescriber and do ask him in case of any doubts. Usually, it is to be given in single nostril once daily. To start with we take 1 spray in left nostril on day 1, followed by right nostril on the second day. Continue to take the medicine inside the nose by switching nostrils every alternate day. Each bottle is set to deliver 30 doses. Do not use the bottle after 30 days.

Is it fine to use Knogle 200IU Nasal Spray in pregnant women?

Generally, Knogle 200IU Nasal Spray is not recommended for pregnant women. However, enough evidence is not available to suggest risk associated with the use of Knogle 200IU Nasal Spray causing birth defects or miscarriage in pregnant women. Knogle 200IU Nasal Spray should be used in pregnant women with utmost caution. It is used only if the prescribing doctor finds potential benefit to be much larger than the risk involved.

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Related lab tests

Calcium

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 758, 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1283-84, 1294.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 184-85.
Drugs.com. Calcitonin. [Accessed 02 Apr. 2019] (online) Available from:
Calcitonin. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2011. [Accessed 02 Apr. 2019] (online) Available from:

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.