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Nyrin 50mg Injection
Prescription Required
Product introduction
Nyrin 50mg Injection is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used to treat overdose of methotrexate.
Nyrin 50mg Injection is used to protect the body cells against the harmful effects of anti-cancer medicines during treatment
Nyrin 50mg Injection is used to protect the body cells against the harmful effects of anti-cancer medicines during treatment
Uses of Nyrin Injection
Benefits of Nyrin Injection
In Prevention of Harmful effects of methotrexate
Nyrin 50mg Injection helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Nyrin 50mg Injection will prevent the other side effects such as anemia.
Side effects of Nyrin Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nyrin
- Injection site reactions (pain, swelling, redness)
How to use Nyrin Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Nyrin 50mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Nyrin 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Nyrin 50mg Injection during breastfeeding is not available. Please consult your doctor.
Driving
SAFE
Nyrin 50mg Injection does not usually affect your ability to drive.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Nyrin 50mg Injection in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Nyrin 50mg Injection in patients with liver disease. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Nyrin 50mg Injection
₹240.0/Injection
Leucovorin Injection
Dabur India Ltd
₹250/injection
4% costlier
Lucal 50mg Injection
Celon Laboratories Ltd
₹267.66/injection
12% costlier
Biovorin 50mg Injection
Biochem Pharmaceutical Industries
₹326/injection
36% costlier
Leucorin 50mg Injection
Samarth Life Sciences Pvt Ltd
₹358/injection
49% costlier
Recovorin 50mg Injection
Zydus Cadila
₹265.62/injection
11% costlier
Quick tips
- You have been prescribed Nyrin 50mg Injection to reduce the side effects of the medicine methotrexate.
- Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
- Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Nyrin 50mg Injection may counteract the antiepileptic effects.
Fact Box
Chemical Class
Glutamic acid Derivatives
Habit Forming
No
Therapeutic Class
BLOOD RELATED
Action Class
Cytoprotective agents- methotrexate
Patient concerns
FAQs
What is Nyrin 50mg Injection used for?
Nyrin 50mg Injection is used to prevent harmful effects of methotrexate (cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Nyrin 50mg Injection is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.
What is megaloblastic anemia?
Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency. How long does it take for Nyrin 50mg Injection to work?
How long does it take for Nyrin 50mg Injection to work?
Nyrin 50mg Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.
What are some of the laboratory tests conducted before or during the treatment with Nyrin 50mg Injection?
Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Nyrin 50mg Injection. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Nyrin 50mg Injection contains calcium.
What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Nyrin 50mg Injection?
Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Calcium folinate. Hurley, Maidenhead: Hospira UK Ltd.; 2003 [revised Jan. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
- Levoleucovorin. Parsippany, New Jersey: Actavis Pharma; 1952 [revised Sep. 2016]. [Accessed 26 Mar. 2019](online) Available from:
Marketer details
Name: Vhb Life Sciences Inc
Address: 50-AB, Government Industrial Estate, Charkop Naka, Kandivali West , Mumbai - 400067, Maharashtra, India
Country of origin: India
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MRP
₹240
Inclusive of all taxes
5.0 ml in 1 vial
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