Osorifa 450mg Capsule is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. It may be used alone or in combination with other medicines to fight serious infections.

It is an antibiotic.

Uses of Osorifa Capsule

Tuberculosis (TB)

Benefits of Osorifa Capsule

In Tuberculosis (TB)

Osorifa 450mg Capsule is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Osorifa Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Osorifa

Low blood platelets
Dizziness
Vomiting
Nausea
Fever
Abdominal pain
Skin rash
Hepatitis (viral infection of liver)
Headache
Chills
Paradoxical reactions
Increased aspartate aminotransferase
Increased alanine aminotransferase
Increased bilirubin in the blood

How to use Osorifa Capsule

Take this medicine in the dose and duration as advised by your doctor. Osorifa 450mg Capsule is to be taken empty stomach.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Osorifa 450mg Capsule.

Pregnancy

CONSULT YOUR DOCTOR

Osorifa 450mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Osorifa 450mg Capsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Osorifa 450mg Capsule may cause side effects which could affect your ability to drive.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.

Kidney

CAUTION

Osorifa 450mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Osorifa 450mg Capsule may be needed. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Osorifa 450mg Capsule in patients with liver disease. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Osorifa 450mg Capsule

₹4.27/Capsule

R-Cin 450 Capsule

Lupin Ltd

₹5.54/capsule

30% costlier

TRICIN 450MG CAPSULE

Zee Laboratories

₹5.5/capsule

29% costlier

RIFAMPILA 450MG CAPSULE

Albert David Ltd

₹6.04/capsule

41% costlier

Rimpacin 450mg Capsule

Zydus Cadila

₹71.43/capsule

1573% costlier

Grifa 450mg Capsule

Gracure Pharmaceuticals Ltd

₹6.5/capsule

52% costlier

View all substitutes

Quick tips

Your doctor has prescribed Osorifa 450mg Capsule to cure your infection and improve symptoms.
It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food.
Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
Tell your doctor about all other medicines you are taking as Osorifa 450mg Capsule can interact with many medicines.
Avoid taking hormone-based birth control methods as Osorifa 450mg Capsule may decrease their effectiveness.
Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

RNA polymerase inhibitors- Rifamycins

Patient concerns

My daughter is given tb medicine even though she is not infected taking these medicine will cause tb???

Dr. Rahul Yadav

Paediatrics

Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis.

Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment?

Dr. Anshum Aneja Arora

Pulmonology

If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis

Doctor asked me to do TB GOLD test. But there is no lab test on 1mg with so name. Finally I searched for tuberculosis test and I found two test. 1 is Mycobacterium tuberculosis and other 1 is Mycobacterium tuberculosis sputum. Kindly tell me which test is to be selected and proceeded further.

Dr. Gopal Samdani

Paediatrics

Please follow your doctors advise as he has clinical examination data with him. He can advise you for place where you can do TB gold

FAQs

Is rifampin a penicillin/amoxicillin/sulfa drug?

No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Is rifampin bacteriostatic or bactericidal?

Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Is rifampin an inducer or inhibitor?

Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

What is R-cin 600 used for?

R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

What is R-cinex/Macox plus/R-cinex 600?

R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Does rifampin cause headaches?

Yes. Headache is a possible side effect of rifampin

Does rifampin change urine color/turn urine orange?

Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Does rifampin cause liver damage?

Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

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Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1213-14.
Drugs.com. Rifampicin. [Accessed 01 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from:

Marketer details

Name: Osho Pharma Pvt Ltd

Address: Plot No.2404, Phase IV, GIDC Estate, Vatva, Ahmedabad-382445 (Gujarat).

Country of origin: India

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