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Written By
Dr. Sakshi Sharma
BDS
Reviewed By
Dr. Ashish Ranjan
MD (Pharmacology), MBBS
Last updated
05 Dec 2023 | 06:15 PM (IST)

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Piroxicam 20mg Capsule

Prescription Required

Product introduction

Piroxicam 20mg Capsule is a pain-relieving medicine. It is used to treat moderate to severe pain in conditions such as osteoarthritis and rheumatoid arthritis. It helps relieve pain and swelling in the joints and muscles.

It is a non-steroidal anti-inflammatory drug (NSAID).

Uses of Piroxicam Capsule

Benefits of Piroxicam Capsule

In Pain relief

Piroxicam 20mg Capsule is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis or even after a dental (tooth-related) surgery.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Piroxicam Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Piroxicam

  • Vomiting
  • Stomach pain
  • Nausea
  • Headache
  • Dizziness

How to use Piroxicam Capsule

Take this medicine in the dose and duration as advised by your doctor. Piroxicam 20mg Capsule is to be taken with food.

Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Piroxicam 20mg Capsule.
Pregnancy
CONSULT YOUR DOCTOR
Piroxicam 20mg Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Piroxicam 20mg Capsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Piroxicam 20mg Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Piroxicam 20mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment of Piroxicam 20mg Capsule may be needed. Please consult your doctor.
No dose adjustment is recommended in patients with mild to moderate kidney disease. Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Piroxicam 20mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Piroxicam 20mg Capsule may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Piroxicam 20mg Capsule
₹6.7/Capsule
Dolonex 20mg Capsule
Pfizer Ltd
₹7.74/capsule
25% costlier
Pirox 20 Capsule
Cipla Ltd
₹6.05/capsule
2% cheaper
Zeepain 20mg Capsule
Lark Laboratories Ltd
₹2.75/capsule
56% cheaper
Doloswift 20mg Capsule
Ind Swift Laboratories Ltd
₹0.47/capsule
92% cheaper
Mobidin 20mg Capsule
Centaur Pharmaceuticals Pvt Ltd
₹1.66/capsule
73% cheaper

Quick tips

  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Piroxicam 20mg Capsule helps relieve pain and swelling of various joints and muscles.
  • Take it with food to avoid stomach upset.
  • Your doctor will prescribe you the lowest effective dose of this medicine for the shortest possible time necessary to relieve your symptoms.
  • It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness. 

Fact Box

Chemical Class
Enolic acid Derivatives
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
Action Class
NSAID's- Non-Selective COX 1&2 Inhibitors (enolic acids)

Patient concerns

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I am suffering from sciatica. I am on voveran and piroxicam 20mg. Still no relief from pain. Plz suggest any other instant pain relief as I have to travel 7 hours important journey. Waiting for a fast response. Thank you.
Dr. Sunil Sekhri
Diabetology
Medicines are adequate. Do hot fomentation and start physiotherapy as soon as possible . Get an MRI done to a assess the condition
MORE
Severe headaches, extreme anxiety, mood swings, insomnia, Hi sir/mam actually my queries are that are These the best medicines that dr. Shashi had prescribed me and my second question is for my headaches which is increasing from few days dr. Had prescribed me piroxicam ( dolonex dt 20mg) but I have read about it that it is taken during joint pains. So please lead me to a fair decision. Thanks PATIENT from chandigarh You can contact me at
Dr. Ambrish Dharmadhikari
Psychiatry
Thank you for your query. There is no such thing as best medicine, medicine choice depends on many things. And doctor must have chosen medication which suits you best. They usually differ from person to person. Piroxicam is pain killer be it joint pain or headache, it's property to act on pain is being used for you. I hope I have answered your query. Feel free to ask more. - Dr. Ambrish Dharmadhikari Consultant Psychiatrist, Mumbai
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FAQs

What is the difference between Piroxicam 20mg Capsule and diclofenac?

Both Piroxicam 20mg Capsule and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Piroxicam 20mg Capsule.

What is the difference between Piroxicam 20mg Capsule and naproxen?

Both Piroxicam 20mg Capsule and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Piroxicam 20mg Capsule.

What is the difference between Piroxicam 20mg Capsule and meloxicam?

Both Piroxicam 20mg Capsule and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Piroxicam 20mg Capsule.

What is the difference between Piroxicam 20mg Capsule and ketoprofen?

Both Piroxicam 20mg Capsule and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Piroxicam 20mg Capsule. Ketoprofen gel also showed excellent tolerability.

What is the difference between Piroxicam 20mg Capsule and tramadol?

Piroxicam 20mg Capsule is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

What is the difference between Piroxicam 20mg Capsule and nimesulide?

Both Piroxicam 20mg Capsule and nimesulide are pain killers. However, Piroxicam 20mg Capsule is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Can Piroxicam 20mg Capsule be used in the treatment of chikungunya?

Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Piroxicam 20mg Capsule or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Piroxicam 20mg Capsule.

Are Piroxicam 20mg Capsule and aspirin same?

No. Piroxicam 20mg Capsule and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Can Piroxicam 20mg Capsule be used along with dexamethasone?

No. Piroxicam 20mg Capsule should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Can Piroxicam 20mg Capsule be used with methocarbamol?

Yes. Methocarbamol can be used with Piroxicam 20mg Capsule as no serious side effects are known. Inform your doctor before starting any of the medication.

Can Piroxicam 20mg Capsule be used along with paracetamol?

Yes. Paracetamol can be used with Piroxicam 20mg Capsule as no serious side effects are known. Inform your doctor before starting any of the medication.

Is Piroxicam 20mg Capsule a NSAID?

Yes. Piroxicam 20mg Capsule is a non-steroidal anti-inflammatory drug (NSAID).

Is Piroxicam 20mg Capsule a sulfa drug?

Piroxicam 20mg Capsule is a sulphur containing compound. Piroxicam 20mg Capsule can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Is Piroxicam 20mg Capsule a blood thinner?

No. Piroxicam 20mg Capsule is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Is Piroxicam 20mg Capsule a muscle relaxant?

No. Piroxicam 20mg Capsule is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Is Piroxicam 20mg Capsule a narcotic?

No. Piroxicam 20mg Capsule is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Can Piroxicam 20mg Capsule be used in hypertension?

No. Piroxicam 20mg Capsule is not a medication to control hypertension. It is important to note that Piroxicam 20mg Capsule decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam 20mg Capsule.

Can Piroxicam 20mg Capsule be used along with Losartan?

No. Piroxicam 20mg Capsule should not be combined with Losartan. It is important to note that Piroxicam 20mg Capsule decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam 20mg Capsule.

Can Piroxicam 20mg Capsule be used with Lisinopril?

No. Piroxicam 20mg Capsule should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam 20mg Capsule.

Can Piroxicam 20mg Capsule be used with calcium channel blocker?

Yes. Piroxicam 20mg Capsule can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Can Piroxicam 20mg Capsule be used with Tizanidine?

Yes, Piroxicam 20mg Capsule can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Why is beta cyclodextrin added to Piroxicam 20mg Capsule?

Yes. Piroxicam 20mg Capsule can be combined with beta-cyclodextrin. Research has shown that combining Piroxicam 20mg Capsule with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Are there any alternatives of Piroxicam 20mg Capsule?

Yes. There are alternatives to Piroxicam 20mg Capsule. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

What are the contraindications for Piroxicam 20mg Capsule?

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Can Piroxicam 20mg Capsule be used in the treatment of allergy?

No. Piroxicam 20mg Capsule is not a drug to treat allergy. It is a pain killer.

How long does Piroxicam 20mg Capsule work?

Piroxicam 20mg Capsule is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Can you get high by using Piroxicam 20mg Capsule?

No. Piroxicam 20mg Capsule is not known to cause high. It is a non-narcotic painkiller.

Can Piroxicam 20mg Capsule be used to treat menstrual cramp?

Piroxicam 20mg Capsule is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Can I use Piroxicam 20mg Capsule for a migraine?

Piroxicam 20mg Capsule is not approved for the treatment of migraine. Research studies have shown that Piroxicam 20mg Capsule is effective in significantly decreasing the pain associated with migraine without aura.

Is Piroxicam 20mg Capsule effective in back pain management?

Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Piroxicam 20mg Capsule as the cause of back pain can be different for different person.

Is Piroxicam 20mg Capsule affective in gout management?

Yes. Piroxicam 20mg Capsule can be given for the treatment of acute gout. Research studies have shown Piroxicam 20mg Capsule to be highly effective in the treatment of acute gout.

Can you donate blood when on the medication with Piroxicam 20mg Capsule?

Yes. You can donate blood when on Piroxicam 20mg Capsule. Do inform your doctor before donating blood.

Can I use Piroxicam 20mg Capsule if I am a diabetic?

Piroxicam 20mg Capsule in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Piroxicam 20mg Capsule so taking piroxicam can lead to increased risk of renal failure by many folds.

Can I use Piroxicam 20mg Capsule if I have a deranged renal function?

No. Piroxicam 20mg Capsule should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Can Piroxicam 20mg Capsule lead to skin reactions?

Yes. Piroxicam 20mg Capsule is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Can I use Piroxicam 20mg Capsule if I am pregnant?

No. Piroxicam 20mg Capsule should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Can I use Piroxicam 20mg Capsule if I have peptic ulcer disease?

No. Piroxicam 20mg Capsule is contraindicated in cases of active peptic ulcer disease. Piroxicam 20mg Capsule is known to cause gastric ulceration and bleeding.

Can I use Piroxicam 20mg Capsule if I have asthma?

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Can Piroxicam 20mg Capsule lead to difficulty in conception?

Yes. Piroxicam 20mg Capsule can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Can Piroxicam 20mg Capsule be used with diuretics?

No. Piroxicam 20mg Capsule should not be used with diuretics. Piroxicam 20mg Capsule reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Can Piroxicam 20mg Capsule be used with lithium?

No. Piroxicam 20mg Capsule should not be used with lithium. Piroxicam 20mg Capsule leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Can Piroxicam 20mg Capsule be used with warfarin?

No. Piroxicam 20mg Capsule should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

What increases the chances of getting a gastric ulcer when I am already taking Piroxicam 20mg Capsule?

The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Piroxicam 20mg Capsule?

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

What are the serious side effects of Piroxicam 20mg Capsule?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. PubChem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  6. Piroxicam. Feb. 2015. [Accessed 02 Apr. 2019] (online) Available from:External Link
  7. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:External Link
  8. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:External Link

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