Purinol 300mg Tablet is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals that can appear around your joints and kidneys and cause pain. This medicine helps to keep uric acid levels low.

Purinol 300mg Tablet should be taken after food. You should keep taking it as recommended by your doctor even when you are not having a gout attack. If you stop, your symptoms may get worse because more crystals form in your joints and kidneys. You can help yourself by making some changes to your diet and drinking plenty of fluids.

Some of the common side effects of this medicine are nausea, diarrhea, increased serum glutamic oxaloacetic transaminase and serum glutamate pyruvate transaminase, and increased alkaline phosphatase. Your doctor may help with ways to reduce or prevent these symptoms. Some people may get a severe allergic reaction that needs urgent medical attention. Talk to your doctor straight away if you get symptoms of liver disease including nausea that does not stop, yellowing skin or eyes, or dark urine.

To make sure it is safe for you, before taking this medicine, let your doctor know if you have or have had heart failure, heart problems, stroke, kidney or liver disease, or thyroid problems. Do not use this medicine if you are pregnant or breastfeeding. Check with your doctor. You will be asked for regular blood tests to check that your liver is working properly.

Uses of Purinol Tablet

Treatment of Gout

Benefits of Purinol Tablet

In Treatment of Gout

Purinol 300mg Tablet is used to prevent and treat gout. Gout is caused by too much uric acid in your body. When the level becomes too high, crystals may form in and around certain joints and your kidneys. This can cause sudden and severe pain, redness, warmth, and swelling. This medicine works by preventing crystals from forming and reducing the levels of uric acid in your blood. This makes it less likely that you will suffer the symptoms and make them milder if you do have them. It is usually for long-term treatment and should be taken regularly until the dose is completed.

Side effects of Purinol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Purinol

Diarrhea
Nausea
Elevated serum glutamic oxaloacetic transaminase
Elevated serum glutamic pyruvic transaminase
Increased alkaline phosphatase level in blood

How to use Purinol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinol 300mg Tablet is to be taken with food.

How Purinol Tablet works

Purinol 300mg Tablet is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Purinol 300mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Purinol 300mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Purinol 300mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Purinol 300mg Tablet may cause side effects which could affect your ability to drive.
Occasionally drowsiness, dizziness or vertigo, ataxia and visual disturbances, may occur when taking Purinol 300mg Tablet. This may affect your driving ability.

Kidney

CAUTION

Purinol 300mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Purinol 300mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Purinol 300mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Purinol 300mg Tablet may be needed. Please consult your doctor.

What if you forget to take Purinol Tablet?

If you miss a dose of Purinol 300mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Your doctor has prescribed Purinol 300mg Tablet to reduce episodes of gout attack.
Take Purinol 300mg Tablet with food to avoid stomach upset.
Take plenty of fluids (2-3 litres) daily while on Purinol 300mg Tablet.
Notify your doctor if you develop a rash. This could be a sign of allergy and should go away on discontinuing Purinol 300mg Tablet.
When you first start taking this medicine, you might have more gout attacks. Do not stop Purinol 300mg Tablet on having an acute attack of gout as that could make an attack worse.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Do not consume alcohol while taking this medicine as it may cause your gout to flare up.

Fact Box

Chemical Class

Pyrazolo Pyrimidine Derivative

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Xanthine oxidase Inhibitors-gout

FAQs

What is the best time of the day to take Purinol 300mg Tablet?

Purinol 300mg Tablet can be taken at anytime of the day but preferably should be taken at the same time each day so that you remember to take it. It is usually prescribed once daily and should be taken after meals. If the dose exceeds 300 mg or if your stomach is upset, you can take it in divided doses as advised by your doctor.

Why do I still get gout while taking Purinol 300mg Tablet?

If you have started taking Purinol 300mg Tablet, you may experience an increase in attacks of gout (severe pain, swelling, and redness). However, these attacks usually become shorter and less severe after several months of therapy. The possible reason for increased attacks could be gradual breakdown of uric acid crystals, causing fluctuations in uric acid levels in the blood. To prevent such painful events, your doctor may advise to take colchicine with Purinol 300mg Tablet, as it can suppress the gouty attacks.

How long does it take for Purinol 300mg Tablet to lower uric acid levels?

It may take several months before you start feeling better or notice any significant reduction in attacks of gout (severe pain, swelling, and redness). Initially after starting Purinol 300mg Tablet you may experience gouty attacks. Continue taking Purinol 300mg Tablet even if you do not experience any considerable relief from the attacks. Do not stop taking Purinol 300mg Tablet without consulting your doctor. Your doctor will prescribe you another medicine along with Purinol 300mg Tablet to prevent the initial attacks. It may take up to years for the body to completely get rid of all uric acid crystals.

What if I take alcohol while taking Purinol 300mg Tablet?

You should refrain yourself from consuming alcohol while taking Purinol 300mg Tablet as this could make your condition worse. Also, you should avoid all foods that are rich source of proteins as it will help to prevent attacks of gout. Consult your doctor for a detailed list of food items which need to be avoided. It is also recommended that you drink at least 8 glasses of water or other fluids while taking Purinol 300mg Tablet, unless your doctor has advised otherwise.

Does Purinol 300mg Tablet cause drowsiness?

Yes, Purinol 300mg Tablet may cause drowsiness in some people. It can even make you feel giddy (dizzy) or you may have problems with coordination. It would be best to avoid driving or operating machinery if you experience these side effects. However, if it is unavoidable then extreme caution should be exercised while performing such tasks.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 638-39.
Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 996-97.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 40-42.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
CiplaMed. Allopurinol [Prescribing Information]. [Accessed 20 Feb. 2024] (online) Available from:

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