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Written By
Dr. Love Sharma
PhD (Pharmacology), PGDPRA
Reviewed By
Dr. Varun Gupta
M.Pharm, MBBS
Last updated
25 Nov 2023 | 11:59 PM (IST)

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Home>Rizide>rizide 450 mg/300 mg tablet

Rizide 450 mg/300 mg Tablet

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Introduction of Rizide Tablet

Rizide 450 mg/300 mg Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Rizide 450 mg/300 mg Tablet is a combination of rifampicin and isoniazid.

Uses of Rizide Tablet

Benefits of Rizide Tablet

In Treatment of Tuberculosis (TB)

Rizide 450 mg/300 mg Tablet is a combination of medicines that is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Rizide Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Rizide

  • Dark colored urine
  • Rash
  • Vomiting
  • Jaundice
  • Fever
  • Increased liver enzymes
  • Nausea
  • Peripheral neuropathy (tingling and numbness of feet and hand)

How to use Rizide Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rizide 450 mg/300 mg Tablet is to be taken empty stomach.
Avoid Rizide 450 mg/300 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Safety advice

Alcohol
UNSAFE
Consuming alcohol while taking Rizide 450 mg/300 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Rizide 450 mg/300 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Rizide 450 mg/300 mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Rizide 450 mg/300 mg Tablet may cause side effects which could affect your ability to drive.
Rizide 450 mg/300 mg Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Kidney
CAUTION
Rizide 450 mg/300 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Rizide 450 mg/300 mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Rizide 450 mg/300 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Rizide 450 mg/300 mg Tablet may be needed. Please consult your doctor.
Use of Rizide 450 mg/300 mg Tablet is not recommended in patients with severe liver disease.

What if you forget to take Rizide Tablet?

If you miss a dose of Rizide 450 mg/300 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Rizide 450 mg/300 mg Tablet
₹0.07/Tablet
Macox Plus Tablet
Macleods Pharmaceuticals Pvt Ltd
₹11.92/tablet
16929% costlier
Akt 2 Tablet
Lupin Ltd
₹11.39/tablet
16171% costlier
Mycocox Tablet
Cadila Pharmaceuticals Ltd
₹7.6/tablet
10757% costlier
RF Compound 450 mg/300 mg Tablet
Sunij Pharma Pvt Ltd
₹5.81/tablet
8200% costlier
Vicox 2 Tablet
Shrinivas Gujarat Laboratories Pvt Ltd
₹7.9/tablet
11186% costlier

Quick tips

Rizide Tablet

  • You have been prescribed Rizide 450 mg/300 mg Tablet for the treatment of tuberculosis.
  • Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
  • Take it on an empty stomach, preferably at the same time everyday.
  • It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Rizide 450 mg/300 mg Tablet as this may increase the risk of side effects on the liver.
  • Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Rizide 450 mg/300 mg Tablet as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking Rizide 450 mg/300 mg Tablet.

Fact Box

Habit Forming
No
Therapeutic Class
ANTI INFECTIVES

Patient concerns

Patient concerns

arrow
My daughter is given tb medicine even though she is not infected taking these medicine will cause tb???
Dr. Rahul Yadav
Paediatrics
Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis.
MORE
Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment?
Dr. Anshum Aneja Arora
Pulmonology
If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis
MORE
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User feedback

FAQs

Rizide Tablet

What is Rizide 450 mg/300 mg Tablet?

Rizide 450 mg/300 mg Tablet is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

What is the most important information I should know about the Rizide 450 mg/300 mg Tablet?

Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

What is the best time to take Rizide 450 mg/300 mg Tablet?

Take Rizide 450 mg/300 mg Tablet exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Does Rizide 450 mg/300 mg Tablet cause change in urine color/turn urine orange?

Yes, Rizide 450 mg/300 mg Tablet can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.

Does the use of Rizide 450 mg/300 mg Tablet make birth control pills ineffective?

Yes, Rizide 450 mg/300 mg Tablet can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).

What are the instructions for storage and disposal of Rizide 450 mg/300 mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Related lab tests
  • Complete Blood Count
  • Erythrocyte Sedimentation Rate
  • Mycobacterium Tuberculosis DNA PCR - Qualitative
  • Peripheral Smear Examination

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    Disclaimer:

    Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

    References

    1. Isoniazid/rifampicin. Guildford Surrey: Aventis Pharma Limited; 1999 [revised 12 Mar. 2019]. [Accessed on 10 Apr. 2019] (online) Available from:External Link
    2. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. [Accessed 10 Apr. 2019] (online) Available from:External Link
    3. Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 10 Apr. 2019] (online) Available from:External Link

    Marketer details

    Name: Prayas Pharmaceuticals
    Address: Surendranagar Ho, Surendra Nagar-Gujarat - 363001
    Country of origin: India
    NOT FOR SALE
    We do not facilitate sale of this product at present

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