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Written By
Dr. Radhika Dua
MDS, BDS
Reviewed By
Dr. Shilpa Garcha
MD (Pharmacology), MBBS
Last updated
25 Nov 2023 | 11:59 PM (IST)

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Sibofix 400 Tablet

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Product introduction

Sibofix 400 Tablet is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. It is also used to treat infectious diarrhea. It works by killing and stopping the growth of harmful bacteria in the intestines.

It is an antibiotic.

Uses of Sibofix Tablet

  • Treatment of Hepatic encephalopathy
  • Treatment of Infectious diarrhea

Benefits of Sibofix Tablet

In Treatment of Hepatic encephalopathy

Hepatic encephalopathy is a severe liver disease that can cause changes in brain function leading to confusion, tremors (shaking), sleep problems and loss of consciousness. Symptoms include agitation, confusion, muscle problems, difficulty in speaking, and sometimes, coma. Sibofix 400 Tablet lowers the levels of ammonia-producing bacteria in the blood which has harmful effects on the brain. If taken as prescribed, this medicine can improve your brain function and reduce symptoms associated with hepatic encephalopathy.

In Treatment of Infectious diarrhea

Infectious diarrhea is a condition characterized by the sudden onset of loose or watery stools caused by harmful microorganisms in the digestive system. Sibofix 400 Tablet helps treat infectious diarrhea by targeting and stopping the growth of harmful bacteria in the intestines. This medicine interferes with the bacteria's ability to make important proteins they need to survive and multiply. This helps to get rid of the bad bacteria causing the infection, which in turn reduces the diarrhea and helps you feel better.

Side effects of Sibofix Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sibofix

  • Dizziness
  • Nausea
  • Peripheral edema
  • Ascites (accumulation of fluid in the abdominal cavity)
  • Fatigue
  • Depression
  • Nasopharyngitis (inflammation of the throat and nasal passages)
  • Joint pain
  • Rash
  • Muscle pain

How to use Sibofix Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sibofix 400 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sibofix Tablet works

Sibofix 400 Tablet is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sibofix 400 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Sibofix 400 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Sibofix 400 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Sibofix 400 Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Sibofix 400 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Sibofix 400 Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Sibofix 400 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Sibofix 400 Tablet may be needed. Please consult your doctor.

What if you forget to take Sibofix Tablet?

If you miss a dose of Sibofix 400 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Sibofix 400 Tablet
₹43.0/Tablet
Rifagut 400 Tablet
Sun Pharmaceutical Industries Ltd
₹15.2/tablet
65% cheaper
Rcifax 400 Tablet
Lupin Ltd
₹42.69/tablet
1% cheaper
Torfix 400 Tablet
Torrent Pharmaceuticals Ltd
₹40.4/tablet
6% cheaper
Rixmin 400 Tablet
Cipla Ltd
₹38.21/tablet
11% cheaper
Rifastop 400 Tablet
Mankind Pharma Ltd
₹37.9/tablet
12% cheaper

Quick tips

  • Sibofix 400 Tablet reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease.
  • It may cause reddish discoloration of urine. This is normal and harmless.
  • Stop taking Sibofix 400 Tablet and inform your doctor if you have severe diarrhea during or after using Sibofix 400 Tablet.
  • Finish the full course of the medication, even if you feel better.

Fact Box

Chemical Class
Rifamycin derivatives
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
RNA polymerase inhibitors- Rifamycins

Patient concerns

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hepatic encephalopathy fro 12 October
Dr. Saurav Arora
Homeopathy
Dear sir as your case is a chronic case it requires long case taking, examination and regular follow up, therefore, please visit a homeopath so that he can examine you and guide you accordingly.
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I have diabetes, and I'm taking Glycomet for the same. I was recently hospitalised with a lower respiratory tract infection. The antibiotics I was prescribed gave me diarrhoea. Since the antibiotics course is now over, the doctor has now asked me to take Econorm (twice a day) and Sibofix 400 MG (twice a day). My question is whether I can avoid taking Sibofix, because I am afraid my diarrhoea will restart because Sibofix is an antibiotic. Currently my only problems are lack of appetite and a bloated sensation in my stomach.
Dr. Sanjay Bhatt
Physician
Do proper antibiotics course
MORE
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User feedback

FAQs

Should I take Sibofix 400 Tablet with food?

Yes, Sibofix 400 Tablet can be taken orally with or without food with a glass of water. Take it as prescribed by your doctor for the exact period of time.

What does Sibofix 400 Tablet do for the liver?

In liver disease, there is an increased growth of bacteria in the intestine which increases the load of toxins travelling through the body. This further increases the possibility of toxins reaching the brain which can cause abnormal brain function. Sibofix 400 Tablet slows down the growth of bacteria in the gut, decreasing the symptoms in cases of liver disease.

Can Sibofix 400 Tablet cause weight gain?

Usually Sibofix 400 Tablet does not cause weight gain. However, in case you feel there is an increase in weight, you should consult your doctor to determine the reason of weight gain.
Related lab tests
  • Ammonia
  • Culture Stool
  • Liver Function Test
  • Potassium
  • Sodium
  • Stool Examination R/M

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    Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

    References

    1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1215-16.
    2. Rifaximin [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2015. [Accessed 05 Aug. 2023] (online) Available from:External Link
    3. CiplaMed. Rifaximin [Prescribing Information]. [Accessed 05 Aug. 2023] (online) Available from:External Link

    Marketer details

    Name: Dr Reddy's Laboratories Ltd
    Address: Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
    Country of origin: India
    Expires on or after: February, 2025

    A licensed vendor partner from your nearest location will deliver Sibofix 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

    In case of any issues, contact us

    Email ID: [email protected]
    Phone Number: 0124-4166666
    Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
    MRP
    ₹430
    Inclusive of all taxes
    1 Strip
    10.0 tablets in 1 strip
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    Cash on delivery available

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