Acute Myeloid Leukemia (AML)- NPM1 gene Mutations in Bhopal
Understanding Acute Myeloid Leukemia (AML)- NPM1 gene Mutations in Bhopal
What is Acute Myeloid Leukemia (AML)- NPM1 gene Mutations in Bhopal?
Acute Myeloid Leukemia (AML)- NPM1 Gene Mutations analysis is done using highly sensitive and specialized molecular assays. These include real-time polymerase chain reaction (RT-PCR), Sanger sequencing, pyrosequencing (Pyr), and high-resolution melting (HRM) curve analysis.
People who have acute myeloid leukaemia or AML with a normal karyotype (chromosomal makeup) make a significant part of the cytogenetic group of the condition. Therefore, it is crucial to identify the markers (prognostic) that predict the outcomes to the patients more accurately.
In patients with acute myeloid leukaemia and normal cytogenetics, several genes, including NPM1 (nucleophosmin 1), FLT3 (FMS-like tyrosine kinase 3), and CEBPA (CCAAT/enhancer-binding protein alpha), play a vital role in terms of prognostic significance.
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