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Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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MBBS, MD (Pharmacology)
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Differential Lymphocyte Count

You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Differential Lymphocyte Count


What is Differential Lymphocyte Count?

A Differential Lymphocyte Count test measures the relative proportion of lymphocytes in the blood. This test is a key indicator for a range of conditions and diseases that affect the immune system, including infections, allergies, autoimmune disorders, immune system disorders, etc. It is done as part of a complete blood count test that also measures other blood cell types.

Lymphocytes are a type of white blood cell (WBC) and form an important component of the immune system. These cells are responsible for recognizing and attacking foreign substances, such as disease-causing microorganisms (pathogens) as well as other infected or abnormal cells. They help protect the body against a wide range of illnesses. Therefore, abnormalities in the differential lymphocyte count indicate potential health conditions, including infections, allergies, autoimmune disorders, etc. 

A low lymphocyte count, also called lymphopenia, can indicate a weakened immune system characterized by several conditions, such as viral infections, immunodeficiency disorders, autoimmune diseases, etc. A compromised immune system may prompt an increased risk of infections and other illnesses. On the other hand, a high lymphocyte count, also called lymphocytosis, can indicate an overactive immune response which may potentiate the risk of autoimmune disorders, such as rheumatoid arthritis, multiple sclerosis, etc. Lymphocytosis is characterized by a variety of conditions, such as inflammations, allergies, or active infections. 

Usually, a Differential Lymphocyte Count test needs no special preparation; eat or drink as per your daily routine. Its test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your condition, and formulate an overall treatment plan. 

What is Differential Lymphocyte Count used for?

A Differential Lymphocyte Count can be done:

  • As part of a complete blood count test to monitor your overall health.

  • To monitor the overall health of your immune system.

  • To detect and monitor various conditions in the body, such as inflammation, allergy, infections, autoimmune disorders, immune system disorders, etc.

  • To monitor the effectiveness and detect potential side effects of cancer treatments, such as chemotherapy, as these treatments can affect lymphocyte count.

What does Differential Lymphocyte Count measure?

A Differential Lymphocyte Count test measures the proportion of different types of lymphocytes in the blood. Lymphocytes are a type of white blood cells that play an important role in the functioning of your immune system, which helps your body fight disease and infection. 

There are two main types of lymphocytes:

  • T lymphocytes (T cells): T cells control your body’s immune system response and directly attack and kill infected cells and tumor cells.

  • B lymphocytes (B cells): B cells make antibodies. Antibodies are proteins that target viruses, bacteria, and other foreign invaders.

Lymphocytes help your immune system remember every antigen (a foreign substance) it comes in contact with. After an encounter, some lymphocytes turn into memory cells. When these memory cells run into an antigen again, they recognize it and quickly respond. It is also the reason why getting vaccinated can help prevent certain diseases.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Differential Lymphocyte Count


Frequently Asked Questions about Differential Lymphocyte Count

Q. What do high and low lymphocyte counts suggest?

A high lymphocyte count suggests that your body is fighting to protect you from germs that make you sick. Less often, low lymphocyte count is a sign of a more serious condition.

Q. How is a Differential Lymphocyte Count test done?

A Differential Lymphocyte Count test is done using a sample of blood that is withdrawn from a patient’s vein. The blood sample is collected in a vial and sent to the lab for analysis.

Q. Is there any risk associated with a Differential Lymphocyte Count test?

There is no risk associated with this test. However, as a needle is used to prick and take out your blood sample, you may experience bleeding, swelling, or blood collection under the skin, which is usually self-limiting. If the symptoms do not recede, consult your doctor.

Q. Can a Differential Lymphocyte Count test help detect cancer?

A Differential Lymphocyte Count test can provide important information about the relative percentage of lymphocytes present in the blood that helps to detect and monitor certain types of cancers, such as lymphoma, leukemia, etc. However, your doctor may also suggest additional tests to establish a proper diagnosis.
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