Aim

Gliclazide + Pioglitazone + Metformin is a combination of three antidiabetic medicines: Gliclazide + Pioglitazone + Metformin1, Gliclazide + Pioglitazone + Metformin2 and Gliclazide + Pioglitazone + Metformin3. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Gliclazide + Pioglitazone + Metformin1 is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Gliclazide + Pioglitazone + Metformin2 is a thiazolidinedione which increases insulin sensitivity. Gliclazide + Pioglitazone + Metformin3 is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and further increasing the body's sensitivity to insulin.